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In tissues, the ketosteroid isomerase reactions catalyzed by GSTs are strictly dependent on dehydrogenases such as 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase for production of the 3-keto substrates from the corresponding 3-hydroxysteroid precursors, since the GSTs are lacking dehydrogenase activity

Diversos estudos esto a decorrer e esperamos que estes venham a esclarecer a abordagem mais adequada destes doentes

Monitor reactions and adjust protocols with your doctor if side effects persist

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Covelli V, D'Andrea L, Savastano S, et al

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