glutathione fluorometric assay kit biovision Reduced (GSH) Colorimetric CD38 Activity Assay Kit from

Hafeman and W

Data availability All data generated during this study are included in this published article and its supplementary information files, and the raw data of iTRAQ quantitative proteomics generated in this study have been deposited to the ProteomeXchange Consortium ( via the iProX partner repository [44, 45] with the dataset identifier PXD041754

Hypomorph mutations or knockdown of many cohesin genes (SMC1, SMC3, RAD21/SCC1, STAG2) are synthetic lethal with PARPi olaparib which are attributed to the overlapping role of cohesin and PARP1/2 in preventing replication fork collapse (Liu et al, 2018

Extreme temperatures further limit electron transport and enzymatic activity: cold reduces membrane fluidity and inhibits chloroplast biogenesis, whereas heat accelerates protein denaturation (Zhang et al

doi: 10.1186/s13287-022-02923-y

This approach offers a targeted alternative to antibiotics, which can disrupt the gut microbiota and contribute to antibiotic resistance