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98 PARP inhibitors Poly (ADP-ribose) polymerase (PARP) inhibitors, including olaparib, rucaparib, niraparib, veliparib and talazoparib, have been approved for the treatment of BRCA-mutated BC, and several clinical trials (Phase 1: NCT01853306

Consistent with a disabled lipid peroxidation defense, we observed that after one hour of GPX4 inhibition and prior to any cell death, there is a drastic elevation in 2,7-dichlorofluorescein (DCF) staining of ROS which indicates lipid peroxidation in persister cells but not parental cells (Fig

doi: 10.1002/art.1780400113 64 CaoTZhouJLiuQMaoTChenBWuQet al

DOI: 10.1016/s0021-9150(00)00724-3 54

Ornish D, Brown SE, Scherwitz LW, et al

The test is often performed using common two-syllable words