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Price et al., Cell Metabolism report that SIRT1 activation improves mitochondrial function, reduces inflammation, and protects lean mass under metabolic stress

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TLR-signalling is downregulated in skeletal muscle from Cpt1b m/ mice Toll-like receptors (TLRs) are involved in bridging the immune response to metabolic disturbances as a nutrient sensor and as a part of inflammatory signalling 29,30,31