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N Engl J Med (2013) 368(2):14960.10.1056/NEJMcp1113996 3 BerlinHBerlinRBranteG

This is problematic since the functions of these two coenzymes and their metabolic fates are quite different: Consequently, supplementation with methylcobalamin exclusively does not really address the functions of adenosylcobalaminwhich are at least as important as those of methylcobalamin

In 3-KO mice, these reductions were absent, reinforcing the idea that 3-AR plays a necessary role in regulating the response of brown adipose tissue to these agents [2]

Some specific causes include: Certain medical conditions

Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T (2003) Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a singlecenter, prospective, randomized, openlabel study

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