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Many immunomodulatory factors are found in the tegument, the multi-layered outer surface of the parasite which is capable of quick self-renewal after damage, a process mediated by a population of somatic stem cells with a propensity to differentiate into tegument associated cells (147).The factors within the tegument have been extensively examined (148, 149)

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Additionally, NETs facilitate the activation of CD4 + T cells and the phagocytic function of macrophages through inflammasome signaling

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