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Laughlin MH, Simpson T, Sexton WL, Brown OR, Smith JK and Korthuis RJ (1990) Skeletal muscle oxidative capacity, antioxidant enzymes, and exercise training

Consistency gives the best results

p53 represses LDHA expression either by directly binding to its promoter or by promoting degradation of the LDHA transcription factor HIF-1 (Zhou et al., 2019

However, recent attention has been directed towards its immune-regulatory and homeostatic activities

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Given that microglia can exhibit both pro-inflammatory and anti-inflammatory phenotypes depending on the context, future research is likely to explore ways to fine-tune microglial responses to promote neuroprotection and reduce neuroinflammation