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Phase II trial data published in the New England Journal of Medicine (2023) demonstrated meaningful weight reduction in adults with obesity, but the drug has not completed the full regulatory pathway required for MHRA or EMA approval and does not hold a UK marketing authorisation

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Apart from semaglutide, other oral GLP-1 agonists, such as TTP054/TTP-054 and ZYOG1, are under investigation (122)