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These data reveal that reduced dependence on glutamine anaplerosis is an inherent feature of self-renewing pluripotent stem cells and reveal a simple, non-invasive mechanism to select for mouse and human pluripotent stem cells within a heterogeneous population during both embryonic stem cell passage and induced pluripotent cell reprogramming

In the absence of B12, the body can have difficulty producing healthy red blood cells, causing anemia, fatigue, and neurological symptoms including numbness or other cognitive problems

Besides, inhibitors targeting chitin synthase and glycosylphosphatidylinositol pathways are also being developed [147]

however, evidence for lasting metabolic or epigenetic effects is limited and largely theoretical [238]

Antiporter activity in the intestine appears to be co-regulated with intestinal phase I CYP3A4 enzyme

Nelson, Biochemical Pharmacology, 2013 Glutathione depletion and oxidative stress in acetaminophen-induced liver injury , B