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Preclinical studies demonstrate elevated intracellular NAD+ levels following NNMT inhibition, suggesting a role in metabolic energy regulation

Patients who discontinued tirzepatide after 36 weeks of weight loss regained approximately half of their lost weight over the following year, while those who continued treatment maintained their results

The pathomechanism is still unknown

Inclusion criteria were age 1845 years, body mass index 1827 kg/m 2 , and birth control for women

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