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This oxidative stress is accompanied by the upregulation of genes encoding antioxidant proteins (Mesa-Arango et al., 2014)

The currently established dose of PA is 750 mg per day and another study investigating lower doses, 375 and 250 mg per day, failed to show significant benefits on lean body mass [264]

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In contrast, the ZVAD co-treatment failed to suppress the uptake of PI in RSL3-treated 3D PTC spheroids, mirroring tumor cell viability findings in 2D