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under pathological conditions, such as oxidative stress or posttranslational modifications, it may be altered, resulting in an aberrant -folding structure [264, 265]

Trends Pharmacol Sci 27(6):297309 Wani MC et al (1971) Plant antitumor agents

Trigeminal Neuralgia has been named The Suicide Disease because unfortunately, the pain is so excruciating, so intense, so unpredictable and unrelenting that patients say its more painful than childbirth and pain meds often dont touch this level of pain

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