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233, Apr

Evidence (reducing risk of osteonecrosis): In the CCG-1961 study, alternate-week dosing of dexamethasone during delayed intensification was studied with the goal of reducing the frequency of osteonecrosis.[85] Patients with high-risk B-ALL and a rapid early morphological response to induction therapy were randomly assigned to receive either one or two delayed intensification phases

Front Endocrinol (2022) 13

Lancet 341 : 14371439 Barmeyer C et al

In PAH, inhibition of PDH redirects pyruvate conversion to lactate via lactate dehydrogenase A (LDHA), resulting in reduced ATP production compared to OXPHOSa phenomenon termed the Warburg effect