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International Journal of Molecular Sciences, 21 (4), 1446

Additionally, the genetic defect impairs normal neural crest cell migration into the branchial arches, causing craniofacial anomalies and severe conotruncal cardiac defects (interrupted aortic arch) that may require immediate palliative interventions like balloon septostomy

10.3390/toxics12110810 200 TothA.NicksonP.MandlA.BannisterM

However, we did not study reasons of its primary or secondary reduction, but, we assume it is one of the potent factors in promotion of atherosclerosis