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Michael et al

In addition, mild hyperhomocysteinemia (HHcy) associated with methionine synthase reductase (Mtrr) deficiency results in global DNA hypomethylation, disturbances in choline metabolism and short-term memory impairments in mice [65]

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Coderre TJ, Vaccarino AL, Melzack R

High affinity also results in lower yields as target molecules may not dissociate from the ligand during elution