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Similar to the effect of caloric restriction, resveratrol was found to improve obesity and diabetes-related metabolic deregulations via the activation of metabolic sensors, including SIRT and the AMP-activated protein kinase (AMPK) (125), as well as to promote the AMPK-dependent clearance of -amyloid peptide in the brain of an AD mouse model (60)

As a result, the target compound of 3,4-hydroxybutyric acid could be quantitatively obtained without dehydration

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32 CastellinoP.LuziL.SimonsonD

A total of 60 patients were randomized to receive LC (3 g/day, n = 30) or placebo ( n = 30) for 7 days

NADH production flux and mitochondrial CoASH concentration as a function of cytosolic palmitoyl-CoA concentration with a constant CoASH of 600 M