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Notably, Chac1 expression was significantly downregulated by approximately 95% as early as 3 hours after refeeding, and this suppression persisted for at least 12 hours (Figure 6A)

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one study had several flaws (unmatched controls, unclear cancer stage classification), while the best-designed one had negative results [68, 69, 64, 66, 67]

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Statements Author contributions TD: Writingreview and editing, Writingoriginal draft, Visualization, Investigation, Data curation, Conceptualization

Hallford, and G