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Assessing the cytotoxicity of TiO2x nanoparticles with a different Ti3+(Ti2+)/Ti4+ ratio

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3 Neutrophils and NETs Neutrophils, a type of granulocyte, are derived from granulocyte/macrophage precursors in the bone marrow and are produced at a high rate but have a short survival period, accounting for approximately 60%70% of human peripheral blood leukocytes ( ECMO-related complications include a high incidence of acute organ damage

Maes et al., 2011), and reduced activity of the antioxidant glutathione (GSH) in postmortem brain samples (Gawryluk et al., 2011)

Deficiency in GSH regeneration may result in elevated reactive oxygen species (ROS) and oxidative damage