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SMM is a stage between MGUS and multiple myeloma, and patients with SMM have a higher risk of progressing to myeloma than do patients with MGUS

Toxicology 240 , 2537 (2007)

The other way around, M1 macrophages secrete a lot of inflammatory cytokines, such as IL-1, which lead to insulin resistance in the liver, adipose and musculoskeletal tissues, as well as pancreatic -cell malfunction ( 4.5.3 Hypertension The activation of the RAAS and the SNS - which are both involved in regulating the salt-water balance and cardiovascular function - is increased in hypertension