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Side Effects of Immunotherapy for Gastrointestinal Cancer While immunotherapies have shown promising results in GI cancers, they can also cause unique side effects known as immune-related adverse events (irAEs)

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The disruption of immune tolerance leads to aberrant expression of major histocompatibility complex molecules, co-stimulatory molecules, and anti-inflammatory cytokines in the liver, thereby mediating hepatic injury ( + and CD8 + T cells while diminishing the suppressive function of Tregs, as evidenced by biopsy findings from patients experiencing immune-related hepatotoxicity ( + /CD8 + T cells play a crucial role in the digestive system-related AEs mentioned above

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Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence