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In the hyperglycemic clamping experiment, cotadutide was also found to reduce the de novo fat production of the liver during clamping

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Under oxidative stress, excessive ROS such as OH directly attack DNA, causing single-strand or double-strand breaks, activating PARP-1, consuming NAD and ATP, and generating poly(ADP-ribose), resulting in mitochondrial membrane potential loss and the release of apoptosis-inducing factor, ultimately resulting in cell death [252]

Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis

Uricosuric agents like dotinurad enhance UA excretion by targeting specific enzymes involved in purine metabolism

Winther KH, Wichman JE, Bonnema SJ, Hegeds L (2017) Insufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis, based on a systematic review and meta-analysis