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Glossitis and hyperpigmentation of hands due to Vitamin B12 deficiency. B12 leads to melanin synthesis more frequently in people with darker skin. Skin hyperpigmentation was reversed with B12 replacement Vitamin B12 Deficiency and the Nervous System: Beyond Metabolic DecompensationComparing Biological Models and Gaining New Insights into Molecular and Cellular Mechanisms glutamate to glutathione Glutaminases regulate and oxidative stress in cancer Archives of Toxicology glutamate glutathione reductase Participation in One carbon pathway and cognitive skills in children with Down syndrome Scientific Reports One carbon metabolism and glutathione (GSH) synthesis and metabolism. Download Scientific Diagram Full article: Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B12 metabolism

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