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However: It can cause water retention, increased appetite, and insulin sensitivity changes in some users

In some embodiments, the LNP comprises a Lipid of the Disclosure, distearoylphosphatidylcholine (DSPC), cholesterol, and 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (DMG-PEG2000) at a molar ratio of about 48.5:10:40:1.5, respectively

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(xix) an inhibitor of BMP antagonism including, but not limited to, sclerostin, SOST, noggin, chordin, gremlin, and dan [see Massague and Chen, Controlling TGF-beta signaling, Genes Dev., 14: 627-644, 2000