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Over time, persistent follicular inflammation contributes to progressive miniaturization and, in its most severe expression, irreversible fibrosis of the follicular unit

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Additionally, pinocembrin has been shown to restore cognitive function and reduce neuronal apoptosis and hippocampal inflammation in vivo, mainly by inhibiting NLRP3 inflammasome formation, reducing microglial infiltration, and enhancing BNIP3-mediated mitophagy through the JNK-ERK signaling pathway [175]

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