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This personalized approach ensures that IV therapy is neither too frequent nor too infrequent, striking the right balance for maximum effectiveness

4.2.2 Key cytokines and metabolic substrate abnormalities Matrix metalloproteinases (MMP-9, MMP-12) are secreted by macrophages and neutrophils to directly degrade elastic fibers of alveolar walls

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Moreover, intracellular meningococci induce a cellular response, such as caspase-3 activation, that participates both in the inflammatory state and in the disruption of cell-to-cell junctions