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Considering nicotine use disorder (NUD), there are several data supporting beneficial effects of acute or chronic NAC treatment on nicotine reward assessed in self-administration or conditioned place preference rodent models [27, 35,36,37] (Table 1)

To examine the effects of oxidation during processing, in vitro ligand fishing experiments were performed where metabolites were initially extracted in solvent and then passed over the immobilized GST, thereby reducing the potential for spontaneous, or enzyme-catalyzed oxidative reactions

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