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In response to oxidative stress, p62 activates NRF2 by directly binding to its ubiquitin ligase partner KEAP1 during the oxidative stress response

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Most significantly, catalase activity is affected by phosphorylation at the Ser167, Tyr231, and Tyr386 residues

Similarly, the shadow puppet sequence, when a Klown dazzles a group of onlookers with increasingly impressive creatures before consuming them, is a fantastic piece of stop motion by visual effects artist Gene Warren Jr

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