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are members of the IMI (Innovative Medicine Initiative of the EU) EuroPain collaboration, in which the following industry members are represented: Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Esteve, Gruenenthal, Pfizer, UCB Pharma and Sanofi Aventis

Acknowledgments Financial support by Rasht Branch, Islamic Azad University, grant number 4.5830 is gratefully acknowledged

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Several studies indicate that the early lesions occur at the level of the optical nerve, in particular, in the proximity of the head of the optic nerve at the level of the lamina cribrosa

Specifically, in March 2024, resmetirom, a thyroid hormone receptor- agonist [126], was the first drug approved by the United States Food and Drug Administration (FDA) [125]

James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, et al