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For patients who have contraindications to NSAIDs or who do not achieve adequate pain relief with an NSAID, opioids are an option, such as morphine, hydromorphone, or meperidine, keeping in mind that all opioids increase the pressure of the sphincter of Oddi [135]

Glycine can be interchanged with serine 41 , and glutamate can be converted to glutamine 42

Moreover, post-translational modifications of cysteines trigger redox signaling and affect the three-dimensional protein structure

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[DOI] [PubMed] [Google Scholar] 241.Cremer D., Rabeler R., Roberts A., Lynch B