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Additionally, the treatment led to decreased levels of several key SASP factors, including IL-1, IL-6, and TGF-, in testicular tissue

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In addition, increasing ROS and oxidative stress by the aging process attenuate expression and functional activity of SIRT1 with further progress of oxidative stress and activation of inflammatory signaling pathway NF-B leading to advanced inflammatory and oxidative stress injury (Bouchez and Devin 2019)