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When cells respond to chronic hyperglycemia, the expression of NOX enzymes is upregulated, activating angiotensin II type 1 receptor (AT1R) and increasing superoxide production [152153]

10.3389/fphar.2018.00292 16 EnomotoA.ItohK.NagayoshiE.HarutaJ.KimuraT.O'ConnorT.et al (2001)

T lymphocytes are a major source of cytokines

Further analysis of EcGGT in complex with substrate analogs, acivicin and azaserine, revealed that they formed a tetrahedral adduct (structurally analogous to transient acyl-enzyme intermediate) with the enzyme (Wada et al., 2008)

As compared with non-metastatic set up, LOX expression in human HCC cells was significantly enhanced in metastatic set up after interaction with polarized macrophages in vitro

doi: 10.1038/nrg2348 141 WuY.GongW.WangY.YongT.YangF.LiuW.et al