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In current clinical trials of engineered EVs, research efforts have primarily centered on harnessing engineered EVs to deliver therapeutic nucleic acids and functional proteins, and to serve as tumor vaccine platforms [8, 22, 203, 211]

32.6% of participants receiving Symbravo reported pain freedom after 2 hours while 43.9% reported a resolution of the MBS

Importantly, we, for the first time, explored the underlying mechanisms and demonstrated that SP inhibited mtDNA-cGAS-STING or directly suppressed the STING pathway to attenuate inflammation and ferroptosis, eventually mitigating the DSS-induced colitis

A big thank you to all co-authors and collaborators who contributed to this study

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