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There is a lack of good quality clinical evidence that older people have a clinically significant difference in paracetamol metabolism or are at increased risk of toxicity at either therapeutic or supra-therapeutic doses

On the other hand, in the study of gene-environment interactions, it was shown that SNP in the GSTO1 gene, which was related to arsenic metabolism, exhibited significant interactions with cardiovascular disease, coronary heart disease or stroke [99]

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C., Hong, J., Osterberg, M