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We underline that HIF-1 is not merely a passive regulator but plays an adaptive role in the metabolic and pathophysiological alterations associated with cancer

IMC also prevented diet-driven hepatic cholesterol accumulation and caused both upregulation of the host hepatic bile acid synthetic enzyme CYP7A1 and altered the expression of hepatic genes critical for bile acid feedback regulation

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Furthermore, in his textbook Nutritional Medicine, Dr