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Description

The acquired resistance of tumor cells to TKIs is partially reversed by inhibiting IGFBP-1 and the combination of antiangiogenic TKIs and IGFBP-1 inhibitors may be a promising therapeutic strategy for HCC (135)

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The combination also preserves the physiological pulsatile pattern of GH release, as both pathways remain subject to somatostatin feedback

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Human class V alcohol dehydrogenase (ADH5): a complex transcription unit generates C-terminal multiplicity

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Additionally, in contrast to donor tissue, GPX3 clearly also localized to the interstitial matrix in HP and IPF patients (Fig

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