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In the brain stroke, TRPM2 was shown to partake in I/R-induced neuronal apoptosis using TRPM2 knockout mice (Gelderblom et al., 2014)

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A 498 bp DIG labeled probe, which hybridizes 5 upstream of the replacement vector, was generated by PCR using 5 forward primer CTTACAGCATGGGCAGCAGACTC and 5 reverse primer GTCTCCTCCACGGGGGTCAG and Roche labeling kit (catalog 11636090910)

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