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Other investigational agents -Glucocerebrosidase (GCase) is a lysosomal enzyme encoded by the GBA1 gene

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However, at the level of whole tumor tissues, it remains difficult to unequivocally attribute heteroplasmy changes to mitochondrial transfer, as clonal expansion [161], therapy-associated selection pressures [80], and stochastic genetic drift [395] can independently remodel mtDNA composition