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Consequently, mitochondrial-to-mitochondrial RIRR constitutes a positive feedback mechanism that enhances ROS production, potentially resulting in severe mitochondrial and cellular damage (Fig

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Traunecker et al., Nature 331:84-86 (1988).) Fusion proteins having disulfide-linked dimeric structures (due to the IgG) can also be more efficient in binding and neutralizing other molecules, than the monomeric secreted protein or protein fragment alone