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TBK1 plays an indispensable role in innate immune response and antiviral defenses because it is central to multiple pathways that control expression of numerous genes (e.g., those encoding type I and type III IFNs)

This transforms a fleeting local signal into a sustained systemic therapeutic

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Studies demonstrate the potent antioxidant capacity of curcumin by mitigating oxidative damage and restoring the endogenous antioxidant systems after TBI