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While in most cases, CB 1 receptor agonists induce phosphorylation of p38 MAPK in rat and mice hippocampi, THC exhibits varied effects on p38 activation, stimulating it in CHO cells but inhibiting it in the AF5 cell line, while cannabidiol suppresses p38 MAPK in PC12 cells

Sun Damage (Solar Lentigines) Sun damage accumulates slowly

Antioxidants (Basel) (2022) 11(9):1808

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The analysisof MDR mechanisms shows that the sensitivity of tumor cells to the therapy is dependent on cell context--on the combination of peculiarities of the regulatory pathways connected with the species and tissue lineage of the cell and also with genetic alterations arising in the cells during carcinogenesis and tumor progression