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Bioact Mater 14:182205 Han C, Gao RR, Zhou L, Li W (2025) The gutkidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity

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Some researchers adjust escalation timing based on body weight and individual response, but the target doses themselves remain the same across the research population

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Notably, the p-AKT/total AKT ratio does not show a corresponding increase, suggesting that the higher p-AKT signal is mainly driven by increased AKT1 abundance