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10.1016/S0140-6736(02)08713-5 Lancet 11 BartelsM

These can include skin issues, stomach problems, and allergic reactions

Recent advances in the treatment of IBD: Targets, mechanisms and related therapies

doi: 10.1016/j.smim.2017.12.004

While all products entering the nasal cavity will ultimately exit through the oropharyngeal route and out the back of the throat, the goal is to minimize these clearance kinetics to ensure maximum exposure of the active product in the nasal cavity per scenario B

Topiramate attenuates dural vasodilation primarily by inhibiting nitric oxide-mediated release of CGRP from preganglionic fibers of the trigeminal nerve (Akerman and Goadsby, 2005)