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Specific HA fragment sizes also exhibit distinct biological activities, playing pivotal roles in inducing immune defense mechanisms within the intestinal epithelium (222, 223)

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Several transcript variants of this gene encode multiple protein isoforms

Molecules 2020;25

In conclusion, it is speculated that melatonin-loaded EVs can effectively penetrate articular cartilage and selectively target chondrocytes to attenuate the degeneration of articular cartilage by inhibiting oxidative stress, inflammation, and chondrocyte death

10.1074/jbc.C400059200 106 MiyazakiH.AnzaiN.EkaratanawongS.SakataT.JungH.JutabhaP.et al (2005)