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Front Endocrinol (Lausanne) (2020) 11:560

176 (33, 1226), GGT 46 (11-1579), platelets 282x10^3 (24-652), IgG 1380 mg/dL (480-5171), +autoantibody 57%, LSM 6.2 kPa (3.5-63.9)

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In fact, it is not only tumor microenvironments which can educate immune cells since for instance, the GM-CSF can license murine and human monocytes toward their immunosuppressive phenotypes through the PI3K/AKT/mTOR signaling pathway [90]

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Previous studies in pancreatic and breast cancers have shown that tumor-derived EVs or direct tumor cell-adipocyte contact stimulate lipolysis in adipocytes, a response characterized by reduced triglyceride content, increased release of glycerol and free fatty acids, and HSL activation [68-70]