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In a recent meta-analysis, 40 out of 44 studies (90.9%) showed a tumor inhibitory effect of CR in laboratory animals with respect to tumor incidence, progression or metastasis

Current projections suggest that, without effective intervention, nearly two-thirds of adults over 25 years of age could be affected by 2050, corresponding to approximately 3.8 billion individuals [1]

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Understanding the mechanisms involved in this modification mechanism can offer strategies for the development of targeted interventions

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They are critical for the metabolism of carbohydrates, lipids, and proteins