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Over time, the constant excretion of cortisol begins to fatigue the adrenal glands, and because the adrenals produce reserve stores of sex hormones, such as estrogen, progesterone, and testosterone, it may cause the body to steal the materials needed to make these sex hormones and convert them into more cortisol

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Also, studies with ficlatuzumab have demonstrated its ability to reduce the effects of TAFs on proliferation, migration, and invasion in HNSCC [106]

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