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Clinical practice is divided: 50% of clinicians routinely prescribe AOX for elevated SDF, while others use them selectively in patients with risk factors such as smoking, obesity, or advanced paternal age [35]

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If irritation persists, discontinue use, and in the unlikely case of severe irritation seek professional medical advice

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10.1101/cshperspect.a006429 7 AkhtarM.MaikiyoA