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This creates a dangerous bottleneck where highly toxic Phase I intermediates accumulate in the liver, leading to systemic toxicity, severe hepatic inflammation, and a cascading failure of the body's natural waste-removal systems

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Under normal conditions approximately 90% of glucose flows through glycolysis, with a much smaller fraction being channeled through the HMP pathway

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Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient