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As shown in Figure 4FK, ER stress-induced apoptosis signaling pathway levels were substantially down-regulated in the vitamin B12 and 4-PBA co-treatment group relative to the vitamin B12 group

FIGURE 7 Persistent accumulation of ROS induces lipid peroxidation in keratinocyte membranes and structural proteins, resulting in impaired barrier function and increased TEWL (Yang et al., 2022

Peer review Peer review information Nature Reviews Drug Discovery thanks Mark Mattson, Yi Zhu and Richard Faragher for their contribution to the peer review of this work