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It has been estimated that about 50% of women with PCOS are overweight or obese and have reduced insulin sensitivity (224)

When placed in regulatory, promoter, or enhancer regions, genomic DNA methylation is mostly associated with silent chromatin and a lack of transcription [10]

Insulin resistance is a key factor in weight gain and can impede weight-loss efforts

Butterfield DA, Favia M, Spera I, Campanella A, Lanza M, Castegna A (2022) Metabolic features of brain function with relevance to clinical features of Alzheimer and Parkinson diseases

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